Lecture for 4th year medical students at the Faculty of
Medicine King Fahad Medical City, Riyadh, on December 21, 2013
1.0 FUNCTIONAL DIAGNOSES
·
Hypothyroid (slow down)
·
Euthyroid
·
Hypethyroid (speed up)
2.0 BASIS OF DIAGNOSIS
(+ and -)
·
History of presenting symptoms
·
Clinical thyroid assessment
·
Measurements of blood thyroid
hormone levels
·
Antibody studies
·
Thyroid imaging (thyroid technetium
nuclear medicine scan, thyroid ultrasound)
·
Thyroid fine needle biopsy
·
Pathognomonic signs (spot diagnosis)
3.0 STRUCTURED HISTORY
·
Demographic data: age, date, residence
/ water supply (iodine)
·
Presenting symptoms / signs:
background, the 5 questions, previous episodes, current medication,
consequences / disabilities
·
Risk Factors
·
Medical history
·
Surgical history:
·
Family history
·
Social history / habits: Usual diet
, Smoking, Alcohol, Drugs including Analgesics, Occupation, education, hobbies,
Marital status, social support, Living conditions
·
System review: cardiovascular,
respiratory, gastrointestinal, skin, musculoskeletal (growth and development),
reproductive, sensory and nervous etc
·
Closing the interview
·
Summary: what are the main problems?
4.0 PRESENTING SYMPTOMS
OF HYPERTHYROIDISM (thyrotoxicosis)
·
Skin: excessive sweating, itching,
heat intolerance
·
Nervous: Increased
irritability, emotional lability,
malaise
·
Cardio vascular: Palpitations,
dyspnea
·
Musculoskeletal: weakness, tremor
·
Gastro-intestinal: increased appetite,
thirst, vomiting, diarrhea, increased bowel movements, weight Loss despite a
good appetite
·
Reproductive: menstrual
disturbances, loss of libido, gynecomastia
·
Children: excessive height / growth
5.0 PRESENTING SIGNS OF
HYPERTHYROIDISM (thyrotoxicosis)
·
Enlarged thyroid gland (goiter):
diffuse (generalized) or focuses and nodular - Pressure effects: dysphagia,
more for solids than liquids - Dypnea, chocking sensation - Neck pain due to
inflammatory conditions - Malignancy: voice change die to laryngeal nerve
infiltration, hard neck lymph nodes,
·
Cardiovascular: tachycardia, atrial
fibrillation, warm vaso-dilated extremities, systolic HT, cardiac failure
·
Eye: Exophthalmos (proptosis), eye
lid retraction (white sclera seen above iris when patient looks forward), eye
lid lag (upper eye lid lags behind the eyeball when patient is asked to look at
finger moving from up downwards), diplopia, ocular pareses, conjuctival edema
·
Musculoskeletal: Fine tremor of
hands, muscle weakness (patient has difficulty rising up from sitting squatting
position)
·
CNS: Looks anxious, cannot sit
still, irritable, psychosis,
6.0 RISK FACTORS OF
HYPERTHYROIDISM
·
Auto immune: Graves' disease
·
Toxic nodular goiter: multinodular,
solitary
·
Acute thyroiditis - rare
·
Gestational thyrotoxicosis - rare
·
Neonatal thyrotoxicosis - rare
7.0 PRESENTING SYNPTOMS
OF HYPOTHYROIDISM
·
Lethargy, somnolence,
·
Loss of concentration and memory
·
Cold intolerance
·
Parasthesia
·
Deafness and unsteadiness
·
Muscle and joint pains / aches
·
Angina, intermittent claudication
·
Un explained weight gain
·
Constipation
8.0 PRESENTING SIGNS OF
HYPOTHYROIDISM
·
Hypothermia
·
Thyroid shrunken
·
Slowness and sluggishness
·
Voice: husky, deep
·
Skin: dry and cold, thick
·
Face: puffy with peri-orbital edema
and bags under eyes
·
Non pitting myxedema
·
Tendon jerks have a slow relaxation
phase
·
Cerebellar dysfunction with
difficulty in balance
·
Reproductive: Menorrhagia,
infertility, recurrent abortion, galactorrhoea
·
GIT: Intestinal obstruction, Paralytic
ileus,
·
Peripheral edema
·
Hair: dry, coarse, brittle
·
Children: slow growth, poor school
performance
·
Nervous system: coma, depression
9.0 RISK FACTORS OF
HYPOTHYROIDISM
·
Congenital: agenesia, ectopic thyroid
remnants
·
Defective hormone synthesis: iodine
deficiency, drugs (anti thyroid, lithium, amiodarone, interferon)
·
Auto immune: atrophic thyroiditis,
Hashimoto’s thyroiditis, post partum thyroiditis
·
Infective: post sub acute thyroiditis
·
Post irradiation / Post surgery
·
Tumor infiltration
·
Hypopituitarism
·
Peripheral resistance to
thyroid hormone
10.0 SCORING SHEET
(THYROID HISTORY)
Item
|
Gp1
|
Gp2
|
Gp3
|
Gp4
|
Gp5
|
Gp6
|
Gp7
|
Gp8
|
Gp9
|
Gp10
|
Introduction
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Demographics
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Presenting Complaints
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Risk factors
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Medical history
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Surgical history
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Family history
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Social history
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System review
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Closing
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Summary
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NB: Score: 0=not done
1=done not well 2=done well